Amino acid sequence of the basic protein of human brain myelin
نویسندگان
چکیده
منابع مشابه
Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry.
In order to resolve the uncertainties about the primary structure of human myelin basic protein at residues 45-89, the sequence of this peptide and its tryptic fragments were reinvestigated by fast atom bombardment mass spectrometry. The sequence at positions 77-78 was found to be His-Gly and the sequence at positions 83-84 was shown to be Glu-Asn. The Ser at position 56 was not phosphorylated,...
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The amino acid sequences of the encephalitogenic basic protein, A1, from bovine and human myelin are similar, differing by only 11 residues. The sequence reveals that while basic residues are spread randomly over most of the polypeptide chain, several regions (8-10 residues) exist that are nonpolar in character. The bovine protein has 170 residues with molecular weight 18,400. The human protein...
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Abstract Background and Objectives: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease. Mucosal feeding of myelin basic protein binding to the cholera toxin B subunit can reduce the intensity of the immune response in MS patients. Expression system, the domain composition of the fusion protein, accessibility of two domains, codon adaptation index (CAI) and GC contents are v...
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Background and Aims: Since 1998, Iranian poultry industry has been affected by avian influenza (AI) virus, subtype H9N2. The association of high mortality and case report of H5N1 and H9N2 influenza virus in wild birds in recent years raised the suspicion of a possible new genetic modified AI virus. Methods: Partial nucleotide sequences and deduced amino acid of hemagglutinin (HA) genes of 4 H9...
متن کاملDetermination of methylated basic amino acids with the amino acid analyzer. Application to total acid hydrolyzates of myelin basic proteins.
A procedure is described for the direct determination of methyl derivatives of basic amino acids in total acid hydrolyzates of proteins by the use of a Beckman amino acid analyzer operated in the high sensitivity mode with automatic integration. The conditions described permit the separation of ornithine, lysine, 5-hydroxylysine, N’-monomethyllysine, N”-dimethyllysine, histidine, N’-methylhisti...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj1220065pa